WebThe Raf/MEK/ERK signaling was the first MAP kinase cascade to be characterized. It is probably one of the most well known signal transduction pathways among biologists because of its implication in a wide variety of cellular functions as diverse -and occasionally contradictory- as cell proliferation, cell-cycle arrest, terminal differentiation and apoptosis. Web13 apr. 2024 · Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis. Even if radiation or surgery permit an efficient control of the primary tumor, up to 50% of patients subsequently develop metastases, mainly in the liver. The treatment of UM metastases is challenging and the patient survival is very poor. The most recurrent event …
Dual effects of active ERK in cancer: A potential target for …
Web4 mei 2024 · MEK inhibitors (MEKi) have been developed to block signaling in cancers driven by mutations in Ras and Raf. These MEKi, however, can lead to increased signaling through parallel pathways controlled by non-Raf MEK activators, including the c-Jun N-terminal kinase (JNK), p38, ERK5, and nuclear factor-κB (NF-κB) pathways [ 44 ]. WebMAP2K1 is also known as MEK1 (see Mitogen-activated protein kinase kinase ). MEK1 is a meiotic chromosome-axis-associated kinase that is thought to slow down, but not entirely block, sister chromatid recombination. Loss of MEK1 allows inter-sister DSB repair and also inter-sister Holliday junction intermediates to increase. genins claim status
The Raf/MEK/ERK pathway: new concepts of activation
Web2 apr. 2024 · The pathway is responsible for transmitting signals from extracellular growth factors to effectors in the nucleus. It is activated when the growth factors bind to cell surface receptors that activate receptor tyrosine kinases. The signal then continues down to the RAS-RAF-MEK-Extracellular signal-regulated kinase (ERK) pathway . [2,3] Web1 dec. 1993 · to activate MEK. However, in PC12 cells, protein kinase C . functions upstream of . ras, because the dominant negative . ras . can block the pborbol 12-myristate 13-acetate-stimulated . genins preauth form